Europole Mer : research consortium on marine science and technology in Brittany

Proteomic approaches applied to adhesion and co-regulating factors in marine bacteria.

Bacterial biofilms represent the first step in the biological colonization of marine surfaces. Its development is conditioned by complex processes implicating cell adhesion, growth, mobility and communication. In order to study some of these mechanisms, we have focused in two biofilm-associated bacteria: Pseudoalteromonas D41, presenting a strong surface adhesion and P. 3J6, which inhibits the settlement of other biofilm-associated bacteria through its secretome. The outer-membrane proteome analysis of P. D41 shows the strong up-regulation of specific proteins which may be implicated in its adhesion. On the other hand, proteomic analysis of P. 3J6 secretome is currently being carried in order to identify proteins that could have anti-biofilm activity.